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Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]

Advanced experimental techniques, including spatial transcriptome, single-cell (or nuclei) transcriptomics and assay for transposase-accessible chromatin using sequencing, will be instrumental in uncovering the epigenetic and transcriptomic signatures associated with the transformation of astrocytes under neurodegenerative conditions 156

It works quietly in the background, roaming around the body, scavenging for free radicals that can damage our cells

Overproduction of NO can occur in several pathological conditions (e.g., inflammation, endotoxic shock, diabetes, ischemia/reperfusion injury

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