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95 In a 52-week, double-blind, placebo-controlled, phase 2b trial (NCT02279524), Aramchol displayed a placebo-corrected decrease in liver TG, without reaching the prespecified significance ( p = 0.066)

S1P amplifies this effect by binding to hemoglobin complexes associated with 2,3-BPG, pushing them toward the T-state, a structural configuration favoring oxygen release (Sun et al., 2017)

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