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In the forebrain, approximately 20% of synoptically released glutamate reaches the postsynaptic glutamate receptors from the synaptic cleft during synaptic transmission, and the remainder can reach the astrocytes for glutamate re-uptake [170]

therefore, these reactions are termed 'idiosyncratic' DILI (IDILI).4 Many drugs have been identified to cause IDILI in humans.5 Antithyroid drugs-induced hepatic injury is categorized as IDILI.6 Due to its high morbidity and mortality, and unpredictable nature, DILI has become a major clinical challenge.7 Moreover, DILI accounts for a large number of drug withdrawals from the marketplace, or discontinuation of further development of a drug candidate

Inform your doctor if you have kidney problems, or if you have ever had kidney stones

[Characterization of de novo malignancies in liver transplantation]

Theodorou, N