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doi: 10.1111/j.1749-6632.2012.06538.x PMCID: PMC3384703 NIHMSID: NIHMS366557 Zonulin, regulation of tight junctions, and autoimmune diseases Alessio Fasano ~ Physiol Rev

Systemic effects remain less certain because peptides are generally broken down during digestion, which reduces the amount that reaches circulation in active form

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