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Many patients experience fatigue, nausea, or reduced appetite while on GLP-1 or GIP + GLP-1 peptides

Phosphinic peptides often share structural similarities with the transition-state of peptide substrate upon hydrolysis ( Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

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