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KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations

Dihexa targets a persons cognitive function specifically and produces chemicals that the brain requires to enhance memory

It is not approved for human or veterinary use and is not intended for clinical administration, therapeutic treatment, or diagnostic procedures

The presence of an expanded polyQ tract in proteins leads to a self-association that competes with polyQ-mediated interaction with beclin-1 and impairs autophagy in vitro (as observed for ATXN3) and in vivo (as observed for huntingtin), at least in conditions of starvation [85]

In terms of targeting, extracellular vesicles have corresponding ligands on their surface, and through surface binding and endocytosis, they naturally have a delivery advantage (Han et al., 2021b