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Role of HDACs in epilepsy Although the pathogenesis of epilepsy has not been fully established, excitotoxicity, oxidative stress and neuroinflammation are regarded as the triads of epileptogenesis, a process during which triggers of brain insults such as status epilepticus by chemoconvulsants, infection or cerebrovascular disease include and the brain undergoes a cascade of morphological and functional changes prior to the onset of spontaneous recurrent seizures in chronic epilepsy [98], and epilepsy-associated neurodegeneration

Most people do not take vitamin C doses high enough to cause meaningful interaction anyway

Therefore, by blocking the STAT3 signaling pathway, parthenolide could reverse cisplatin resistance in GC (187)

Cells (2018) 7(10):159

They increase proton leakage across the inner mitochondrial membrane, thereby reducing ROS generation [284]