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Specifically, ATF4 binds to the AARE in the SLC7A11 promoter, causing SLC7A11 expression (22)

while respiratory viral infections cause antioxidant enzyme expression/activity inhibition associated with reduced Nrf2 nuclear localization, decreased cellular levels and reduced ARE-dependent gene transcription (Komaravelli and Casola, 2014)

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A 1200 mg/day ibuprofen dose (20 mg/kg/day, assuming an average human weight of 60 kg), would correspond to a treatment of 246.9 mg/kg/day in mice using the dose translation equation (Human equivalent dose (HED) = Animal Dose (mg/kg) Animal Km (3 for mouse)/Human Km (37 for human) 16

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