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Prog Mol Biol Transl Sci (2009) 88:5784

The downregulation of LH-RH receptors creates a state of reversible medical castration

The local effect theory suggests oral administration may actually work better than injection for these purposes

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Subgingival dental plaque is the main etiological agent for initiating inflammatory changes in the periodontal tissue and the cell component of bacteria, which exist in the dental plaque and recruit and activate hyper-responsive polymorphonuclear leukocytes (PMNs), which are innate immune cells that may play both defensive and destructive roles in periodontitis (Nicu and Loos, 2016) and accelerate oxidative stress biomarkers (Ademowo et al., 2020)