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Archives of Pharmacal Research, 30(7), 834-839

We found that the ebselen could significantly promote SGN survival, decrease SGN apoptosis, and reduce intracellular ROS levels after peroxynitrite exposure in vitro , while the deficiency of GPX1 led to opposite patterns of the above effects

In: del MoralAMAguilera GarcaCM, editors

Ko et al., 2017), inhibiting the oncogenic transformation of normal cells through the regulation of relevant genes, tumor growth and development, angiogenesis and metastasis, downregulation of various oncogenic-related molecules and upregulation of tumor suppressor proteins, modulation of reactive oxygen species levels in cells to regulate cell proliferation, survival and apoptosis, and also transformation of the gut microbiota to acquire bioactivity-promoting properties to inhibit cancer development and progression (Anantharaju et al., 2016).Polyphenol combination therapy significantly improves anticancer efficacy and reduces drug resistance and chemotherapeutic toxicity through multi-target synergy