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We highlight the growing body of evidence demonstrating that these polyphenols can synergistically inhibit the aggregation of A and tau, mitigate neuroinflammation, restore mitochondrial function, reduce oxidative stress, and promote neurogenesis

The raw files of proteome datasets can be obtained from the iProX database (www.iprox.org)interactome of PDK1 (accession PXD041705), interactome of Smurf1 (accession PXD045430), identification of Neddylation site in PDK1 (accession PXD041708) and proteome (accessions PXD041740 and PXD051870)