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Description

The frequency of the NUDT15 poor metabolizer phenotype is about 1 in every 50 patients of East Asian descent, so it is more common than the TPMT poor metabolizer phenotype in Europeans

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Thus, some of the oral symptoms in our patients may be related to neuropathic changes of the trigeminal nerve

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There is limited evidence suggesting direct effects on hormone levels

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JV: Conceptualization, Data curation, Investigation, Writing original draft

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This exceptional safety profile was consistent across multiple dose levels, administration routes, and treatment durations

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