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Despite significant individual differences, XpdTTD/TTD mice were found to run 1.37 0.54 km/day on average, compared to 9.37 1.1 km/day seen for wild-type mice, arguing they are indeed less mobile

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Liver glutathione declines 35-50% in aged animals [7] , while brain glutathione drops by at least 50% over adult aging [8]

For vulnerable patient populations, for example, pediatric patients needing long-term medical treatment, drug tolerability and safety should be considered in addition to effectively controlling disease activity

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