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J Pept Res 63(3):324328 DAloisio V (2022) Design, synthesis, and evaluation of serum-stable peptide antagonists of the CGRP receptor as a novel treatment for migraine

Beyond energy conversion, mitochondria are indispensable for a myriad of other cellular processes, including heme and steroid hormone synthesis, calcium ion (Ca 2+ ) buffering to regulate intracellular signaling, and the initiation of apoptosis via the mitochondrial pathway (36)

Epimedii Folium decoction ameliorates osteoporosis in mice through NLRP3/caspase-1/IL-1beta signalling pathway and gut-bone axis

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A similar dietary supplementation was also found to decrease the phosphorylation of PPAR and nuclear factor E2-related factor 2 (Nrf2) and induce upregulation of their downstream targets including -glutathione S-transferase (GST) and adenosine triphosphate-binding cassette transporter A1 (ABCA1) through inhibition of matrix metalloproteinase-1 (MMP-1) (Bozaykut et al., 2014)