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Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]

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Generalized linear mixed effects models were also used to compare the low carnitine status with the normal carnitine status on the number of ASMs, where a canonical log link function was used for Poisson distributed outcome