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MTHFR variants like C677T can raise homocysteine and increase demand on the folate and B12 methylation pathway, but they do not by themselves cause deficiency

If you're targeting a lower dose

That ambiguity is itself a dosing problem: you cannot confidently transfer a Semax dose to Adamax if you cannot confirm the two share a sequence and molecular weight

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It's relatively stable and converts easily into active forms in the body