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however, the dose required was four times that recommended and was associated with adverse cardiac side effects (230)

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This mechanism explains why users often report improvements in stubborn fat deposits that had not responded adequately to diet and exercise alone

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

Interestingly, in chronically insulin treated 3T3-L1 cells and fat explants from insulin resistant mice, only insulin-stimulated glucose uptake is decreased while insulin suppression of lipolysis is intact (121), effects which are explained by selective insulin resistance in adipocytes