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A widely cited Harvard analysis in 2015 reported that more than 75% of sampled flavored e-cigarettes and refill liquids contained diacetyl, which helped drive ongoing scrutiny of flavored e-cigarettes as a potential source of diketone exposure

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To submit the initiative to Parliament, 50,000 signatures are needed, which can be provided online through the Ministry of Justice platform

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In addition to nicotine, treatments that shift GABA A R signaling toward excitation in VTA GABA neurons include abrupt withdrawal from chronic morphine or ethanol, as well as aversive or pain states (Taylor et al., 2015, 2016