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Inadequate function of methionine synthase can lead to an accumulation of homocysteine, which has been associated with increased risk of cardiovascular disease and age-related neurodegenerative disease (e.g., Alzheimers disease)

If you are a strict vegan, for example, you are more likely to suffer deficiencies of various nutrients

B12 Injections and Weight Loss The idea of B12 shots leading to weight loss probably came from the observational studies that linked low vitamin B12 to a higher body-weight: Low vitamin B12 level was associated with obesity and overweight, but not with insulin resistance, metabolic syndrome and gender

However, both are strictly research chemicals

Malabsorption Issues: This is the most prevalent reason for B12 deficiency, even for those with B12-rich diets