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Cycling Approach: Some practitioners implement protocols such as 12 weeks on, 4-8 weeks off to theoretically prevent receptor desensitization, reduce long-term costs, or provide physiological breaks

However, there is no evidence that B12 injections confer any greater benefit than does a good quality B vitamin complex, even in cases of B vitamin deficiency

References Sourced from Neelakantan et al., Biochemical Pharmacology (2018), on NNMT inhibitors reversing diet-induced obesity in mice

The major active ingredients found in lipotropic injections are vitamin B complexes, vitamin B12, carnitine, choline, methionine, and inositol