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Additionally, DZN has been reported to induce mitochondrial permeability transition through a mechanism sensitive to cyclosporin A, EGTA, ruthenium red, and N-ethylmaleimide, potentially leading to mitochondrial Ca 2+ efflux and cytochrome c release triggered by ROS [10]

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Over the past two decades, attention has shifted from rare monogenic disorders to more subtle but widespread genetic polymorphisms in folate-related enzymes