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To further elucidate the site selectivity of the pS-MIPs, we performed mouse brain protein lysate spike-in experiments (spiking level: 5 fmol to 2 pmol) with a phosphoserine peptide (SpS: AVP S PPPA pS PR) from the N-terminus of the mature serine protease HtrA2/Omi
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The mechanism behind oral efficacy is attributed to systemic absorption and downstream peptide signaling rather than localized delivery, though the exact bioavailability percentage in humans remains unquantified
