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Additional information The authors would like to dedicate this article to Dr Fabrice Morel who passed away during the preparation of the manuscript

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Moreover, as tunneling includes multiple injections into the plaque, the trauma around the plaque may transform the late-phase fibrotic stage to an active inflammatory phase, making a proactive, regenerative intervention feasible

Agitation introduces air bubbles and can accelerate oxidative degradation at the air-liquid interface

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