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Recently, several pharmacological agents have been discovered as potential antidepressants

These effects of vitamin D3, as well as a resulting increase in GSH levels, have been functionally documented in cell culture studies (28, 29) and in human subjects (30)

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Figure 2B )

What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint