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The animal experiment results showed that SAC treatment significantly improved weight loss, increased DAI, shortened colon length, and histopathological damage induced by DSS, and was able to inhibit the expression of inflammatory factors such as IL-1, IL-6, and TNF-, and restore the expression of MUC2, promoting the recovery of the mucosal barrier

In addition, studies in humans indicate that GH also stimulates distal tubular Na + absorption which may be essential for the GH-induced distal nephron proton secretion (Fig