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To view a copy of this licence, visit About this article Cite this article Wen, Y., Lin, Z., Jiang, Z

Compounding and the FDA: questions and answers

Inhibition of GCH1 leads to a dysfunctional state of BH4 biosynthesis, resulting in ROS accumulation and ferroptosis (41)

By binding to copper at the active site of tyrosinase and interfering with melanin synthesis intermediates, glutathione reduces overall melanin formation. As a powerful antioxidant, glutathione also reduces free radicalinduced oxidative stress, which is one of the triggers for increased tyrosinase activity and melanin production

The samples were centrifuged at 1000 rpm for 3 min using a KUBOTA 3520 (KUBOTA, Tokyo, Japan), and absorbance was measured at 595 nm using a GeneQuant 1300 spectrophotometer (Biochrome, Cambridge, UK)