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In addition, flavonoids also undergo phase I metabolism mediated by hepatic cytochrome P450 (CYP450) enzymes

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Why the extrapolation is weaker than it looks It is tempting to reason: topical works locally, mechanism is systemic, animals respond to injection, therefore injection should work for skin in people. Each link in that chain is weaker than it appears

At starting doses, the smaller vials are often more cost-effective because you use the entire contents before the 28-day after-puncture expiration

1.7 Epigenetics The study of heritable adjustments in gene expression patterns which do not result from changes the DNA sequence is identified as epigenetic changes