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Nature 568 , 351356 (2019)

This leads to both targeted anti-inflammatory effects at injury sites (where IRR expression is highest) and broader systemic modulation of inflammation, as seen in reduced circulating cytokine levels and improved outcomes in models of widespread conditions like diabetic complications, neuropathy, colitis, and autoimmune diseases, without broadly impairing overall immunity or stimulating red blood cell production

The condition involves inflammation and micro-tearing of the plantar fascia, a thick band of connective tissue that runs along the bottom of your foot from the heel bone to the toes

Research in models of Achilles tendon injury, rotator cuff tears, and ligament damage suggests a strong potential for functional recovery

Giugliani et al