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Recent studies indicate that elevated lactate triggers p300-mediated H3K18 Kla to accumulate at the c-Myc promoter, thereby enhancing both the transcription and stability of c-Myc [107]

Celebi Sozener Z, Ozdel Ozturk B, Cerci P, Turk M, Gorgulu Akin B, Akdis M, Altiner S, Ozbey U, Ogulur I, Mitamura Y, Yilmaz I, Nadeau K, Ozdemir C, Mungan D, Akdis CA

PMID: 41790190 J Alloys Compd2026 Jan 30

This question has been studied by knocking out GOAT: these mice showed an overall decline in the amount of GH release compared to age matched wild-type mice

Abstract Traumatic brain injury (TBI) is increasingly appreciated to be highly prevalent and deleterious to neurological function 1,2