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All these effects of NAC, in combination with other agents such as mannose and chondroitin sulphate, could be furtherly enhanced, providing synergistic effects by targeting different aspects of UTI pathogenesis, including bacterial adhesion, biofilm formation, and immune modulation

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AHK-Cu (Ala-His-Lys-Cu) is a related copper tripeptide found in human plasma that shares the His-Lys copper-binding motif but substitutes alanine for glycine at the N-terminal position, resulting in a slightly different copper coordination geometry and a distinct (though overlapping) gene expression modulation profile