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The ICDRG classification has been revised multiple times to improve standardization, yet inconsistencies remain in distinguishing weak allergic reactions from irritant or doubtful responses [56]

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A weakness is the relative lack of specificity of the potentiation: it is unclear whether either the specific neurons targeted by the transgene, or the nature of their increased firing, realistically recapitulate the elevated neuronal activity seen in functional imaging studies of human OCD