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Informed consent was obtained from the patients, and the study protocol was approved by the Ethics Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine (Permit number: 2024-1360)

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2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating redox homeostasis