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Assays of urinary biomarkers in the RCT were carried out in the Analytical Biochemistry Shared Resource of the Masonic Cancer Center, University of Minnesota as previously described for TNE (molar sum of total nicotine, total cotinine and total 3-hydroxycotinine, where total refers to the unconjugated and glucuronide conjugated forms), 15 total NNAL, 16 PheT, 16 3-HPMA, 17 HMPMA, 17 CEMA, 17 2-HPMA, 18 SPMA, 19 8- iso -PGF 2 , 20 and PGEM

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