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Studies have shown that hypoxia (1% O2 for 24 h) upregulates CAV-1 transcription through activation of NRF1 in endothelial cells, which induces internalization of claudin-5 and autophagic degradation, and accordingly, these effects lead to BBB disruption and trigger HACE (Xue et al., 2022)

The pattern across these concerns: the most alarming-sounding risks (cancer, vitiligo, weight gain) have little to no scientific support for standard oral supplementation, while the more mundane, less-discussed side effect (mild headache) is the one with actual documented occurrence

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Should you receive a new set of shots from the pharmacy that previously provided the painful shots, ask for an additional shot so you can inject yourself before injecting your child to see if the problem has been corrected