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Larger, controlled trials are needed

Research-grade versions of these and related compounds remain in active study across in-vitro and animal models

hepatic macrophages, Kupffer cells, hepatic neutrophils, produce and release large quantities of ROS such as superoxide anion, hydrogen peroxide, nitric oxide, and their derivatives, which target the surrounding tissue and cause oxidative stress intra- or extracelluarly (Bautista et al

A cellular thermal shift assay provided indirect evidence of binding between AG-120 and wtIDH1 (Fig