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(2009) Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a two-hit seizure model
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Product glucuronides are exported from hepatocytes by MRP2 (canalicular, into bile) and MRP3/MRP4 (basolateral, into blood for renal excretion)
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Regarding the timing of onset, most adverse events in this study occurred within 60 days after treatment initiation, indicating a predominantly early-onset pattern
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