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While paracellular transmigration involves passage through intercellular junctionsoften exacerbated by disrupted tight junctions under pathological conditionstranscellular transport is facilitated by various endocytic mechanisms, such as clathrin-mediated endocytosis, macropinocytosis, and lipid raft-dependent pathways 157,158,159,160,161

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Fer-1, DFO, Lip-1, RSL3, Z-VAD-FMK and MT were dissolved in dimethylsulfoxide (DMSO) and diluted in a culture medium at ultimate concentrations (0.5 M with RSL3

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Assessment was done at 505 nm using a microplate reader at 0 and 3 minutes