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The formation of NAPQI is mediated by the cytochrome P450 (CYP) superfamily (Potter et al., 1973), with CYP1A2, 2D6, 2E1, and 3A4 isoforms as the major APAP oxidizing enzymes (Raucy et al., 1989

doi: 10.1016/j.biomaterials.2015.02.079

It is a cluster of overlapping biological dysfunctions that conventional medicines organ-by-organ approach is poorly equipped to address simultaneously