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Konopleva M, Cortes J, S-C C, Hayes K, Giles F, OBrien S, Kantarjian H, Andreeff M , Estey E

GLB tends to decrease when the organism is attacked by pathogens

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Specifically, a better delineation of the embryonic and postnatal roles of IGF-1 signaling in promoting skeletal health is much warranted and will require the use of animal models carrying inducible Cre recombinase transgenes that allow time- and cell-specific deletion of the gene in question