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Although it exhibits muscle wasting, AIA simultaneously activates anabolic pathways (e.g., upregulation of MSTN) and represents a unique RA model for investigating the interplay between inflammatory atrophy and compensatory regeneration

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In the first study, 32 patients with refractory IC/BPS were given intravesical instillation of heparin-lidocaine (20,000 units heparin, 5 mL 4% alkalized lidocaine, 25 mL 7% sodium bicarbonate) weekly for 12 weeks

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