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Very high doses of B12 taken orally may occasionally cause mild gastrointestinal disturbance in some individuals, though this is uncommon

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Celiac disease affects as many as 1 in 300 people in Italy and southwestern Ireland, but is extremely rare in Africa, Japan, and China ( Not et al., 1988)

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Therapeutic modulation of the microbiome shows promise: antibiotics targeting dysbiotic bacteria and fecal microbiota transfer (FMT) reduce lesion growth in preclinical models, while probiotics restoring Lactobacillus dominance improve NK cell activity and reproductive outcomes