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(100) identified cytoplasmic dsDNA accumulation as a crucial cause of fibroblast-like synoviocyte (FLS)-mediated RA synovitis, which drives inflammation primarily via the cGAS/STING pathway in RA-FLSs

Alkylating drugs such as cyclophosphamide, ifosfamide, busulfan and melphalan form inter- and intra-strand DNA cross-links, activating the ATM/ATRp53 axis in granulosa cells and triggering mitochondrial apoptosis

2.2 The role of inflammation in endometriosis The coordinated action of macrophages, endometrial cells, endothelial cells, and activated lymphocytes, along with cytokines and chemokines, alters the abdominal immune microenvironment, facilitating pathological processes including cell proliferation, angiogenesis, lesion adhesion, growth, and invasion (34)

The intestinal epithelium is a unique single-layer structure arranged in the intestinal cavity, forming two distinct tissue domains, namely intestinal crypts and villi