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Rao Q et al (2018) Cryo-EM structure of human ATR-ATRIP complex

The transient release of zinc via the TRPML1 channel contributes to membrane repair and recovery of lysosomal function after damage, highlighting its role in maintaining organelle integrity 105

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Thus, disorders of hereditary iron overload can cause iron deposition in tissues that might result in hypogonadism and impaired spermatogenesis, whereas severe iron deficiency can propagate anaemias that decrease gonadotropin release and sperm counts