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Peng X, Cheng L, You Y, Tang C, Ren B, Li Y, et al

Genetic testing for UGT1A1, GSTM1, GSTT1, NAT2, COMT, and SULT1A1 variants helps identify fixed (non-modifiable) conjugation bottlenecks that require lifelong compensatory strategies

Yes, L-glutamine degrades in complete media over time

Moreover, AmBisome creates a depot inside macrophages that slowly releases the drug in a way that avoids its hemolytic effects and nephrotoxicity (142, 143)