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KOJIC ACID -: It lightens the skin tone by preventing the production of tyrosine, which is responsible for producing melanin

Iron overload modulates follicular microenvironment via ROS/HIF-1/FSHR signaling [J]

In general, it is assumed that the two main limiting factors are the levels of cysteine and of the enzyme gamma-glutamyl-cysteine synthetase (also known as glutamate-cysteine ligase)