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Potential Influence on the Dopaminergic System This is a more speculative but fascinating area

FIGURE 4 Hence, it is the prevailing recommendation among endocrinologists that non-pregnant individuals with PCOS exhibiting abnormal glucose regulation, irrespective of their body weight status, initiate metformin therapy promptly upon diagnosis, with a prescribed duration of treatment lasting at least 36 months

Biochem J 468:7385 Lallement PA, Brouwer B, Keech O, Hecker A, Rouhier N (2014) The still mysterious roles of cysteine-containing glutathione transferases in plants

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Bloodbrain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons