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Iron overload, through ROS production, promotes cellular senescence in surrounding cells, thereby reinforcing a self-sustaining cycle of fibrosis, inflammation, and senescence [27]

A complete workup often reveals numerous contributing factors and root causes, and one common factor is a vitamin B12 deficiency

The small town, at the confluence of the Squamscott and Exeter rivers, has historic mill buildings, well-preserved Colonial and Federal architecture, leafy parks and green spaces, and a compact, walkable downtown