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A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

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Lievre A, Bachet J-B, Le Corre D, Boige V, Landi B, Emile J-F, et al

Symptoms That Signal Immediate Cessation Stop taking glutathione and seek medical attention if you experience: 5,7,8 Allergic reactions: Rash, hives, swelling of the face or throat, or difficulty breathing