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Therefore, they are often used off-label, and regulations differ by country

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The enzyme catalyzes the methylation of nicotinamide (a form of vitamin B3) using S-adenosyl-L-methionine (SAM) as a cofactor, producing 1-methylnicotinamide (1-MNA) as a metabolic byproduct

Several studies have linked B12 deficiency to obesity and a review concluded that B12 deficiency could also lead to a higher percentage of fat accumulation