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Many tumor types, such as breast, lung, and liver cancers, are usually accompanied by high expression of TFR1, and this up-regulation of expression is closely associated with tumor aggressiveness and poor prognosis ( Recent evidence indicates that, beyond TFR1 and DMT1, lipocalin-2 (LCN2, also called neutrophil gelatinase-associated lipocalin or NGAL) provides an alternative iron-delivery pathway that is exploited by multiple tumor types